The Bowery Mission is significant for its 103-year history as the home of the Bowery Mission, a religious-based organization that has fed, housed and cared for countless homeless men on the Lower East Side for more than 130 years. It is constructed with red brick and has four bays of windows with incised stone lintels and sills at the third through fifth stories. The ground floor has three arch-headed openings with keystone lintels, a bracketed cornice and stone banding.