The Ralph and Ann E. Van Wyck Mead House is the only survivor of a row of four houses that functioned as an enclave for the extended family of the very wealthy wholesale grocery and commission merchant Ralph Mead. This house us a fine example of a grand Greek Revival style rowhouse, characterized by its machine-pressed red brickwork laid in stretcher bond, high stoop and areaway with wrought-iron fence, entrance with Italianate style paneled double doors and transom, long parlor-level windows and cast-iron balcony, and denticulated cornice, and is made particularly distinctive by its brownstone portico with Ionic fluted columns supporting an entablature.